It is not necessarily YY1--the frequently forgotten Yin-Yang-2 transcription factor
نویسندگان
چکیده
منابع مشابه
It is not necessarily YY 1 — the frequently forgotten
de Nigris et al. (1) performed an interesting study on the functional implication of YY1 in the VEGF regulatory network, leading to a rationale for using YY1 as a therapeutic target molecule in cancer therapy. However, considering the application of YY1 for antiangiogenic treatment bears a fundamental risk because the observed effects are not necessarily specific for YY1: the YY1 antibody (C-20...
متن کاملTranscription factor Yin Yang 2 is a novel regulator of the p53/p21 axis
Yin Yang 2 (YY2) is a multifunctional zinc-finger transcription factor that belongs to YY family. Unlike the well-characterized YY1, our understanding regarding the biological functions of YY2 is still very limited. Here we found for the first time that in contrast to YY1, which had been reported to be oncogenic, the expression level of YY2 in tumor cells and/or tissues was downregulated compar...
متن کاملIn Vivo Chromatin Targets of the Transcription Factor Yin Yang 2 in Trophoblast Stem Cells
BACKGROUND Yin Yang 2 (YY2) is a zinc finger protein closely related to the well-characterized Yin Yang 1 (YY1). YY1 is a DNA-binding transcription factor, with defined functions in multiple developmental processes, such as implantation, cell differentiation, X inactivation, imprinting and organogenesis. Yy2 has been treated as a largely immaterial duplication of Yy1, as they share high homolog...
متن کاملYY1 transcription factor is not responsible for the negative regulation of hamster Muc1 transcription.
Muc1 is the cell surface glycoprotein abundantly expressed in cancer cells and has been shown to be involved in tumor metastasis and promotion. Recently, we identified a 37 bp segment on the hamster Muc1 promoter with the ability to suppress Muc1 transcription. This 37 bp putative negative regulatory element (NRE) binds to a transcriptional regulator Yin Yang 1 (YY1). In the present study, we e...
متن کاملThe Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation
The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation remain ill-defined. Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1011338108